Follicular mucinosis is a term that encompasses three related entities. Alopecia mucinosa, Urticaria-like follicular mucinosis, and cutaneous lymphoma related. On hair-bearing skin (e.g. scalp), overlying alopecia is notable, hence the term “ alopecia mucinosa” (see Figure 5). Plaques are often composed of densely. Alopecia mucinosa is a skin disorder that generally presents, but not exclusively, as erythematous plaques or flat patches without hair primarily on the scalp.

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Triangular alopecia Frontal fibrosing alopecia Marie Unna hereditary hypotrichosis. Several lymphocytes were seen infiltrating the affected follicular infundibula.

Due to its rarity, epidemiologic studies are limited; no predisposing factors have been identified, and no racial or gender predilection has been established.

Considering the rapid and complete response to antileprosy treatment in muccinosa cases of Alopecia mucinosa three cases described in this paper and the four similar cases described earlier[ 10 ]it is most unlikely that the response was a natural remission of the disease.

Periodic laboratory studies i. Two children, a boy aged 14 years and a girl aged 12 years presented themselves, mucijosa, with a single hypopigmented, hypoesthetic patch on the face. Treatment based on single case series of six patients.

Based on histological findings these cannot be diagnosed as leprosy and will be considered as Alopecia mucinosa. The treatment was, however, started a month later as she was in her village for the alopeci holidays. Clonal FM may regress completely. Case 2 A year-old mucinnosa presented in Marchwith hair loss over left eyebrow and dry hypopigmented skin of adjacent forehead. Quinacrine mg; not available in the United States Corticosteroids, oral—dose not delineated in reports Methotrexate, oral Radiation therapy—skin-directed electron beam or conventional radiation Interferon alfa-2a, intralesional 3 million units biweekly X 5, then monthly Patient Management Discontinue therapy or consider slow titration over months or years after complete response is evident.

Click here for patient related inquiries. Powered By Decision Support in Medicine. Alopecia mucinosa most commonly affects alopeciia, neck and scalp, but any part of the body may be affected. Department of Dermatology, P. Guitart, J, Magro, C. These lesions, however, are always single and show rapid and complete response to antileprosy treatment.


Angiolymphoid hyperplasia with follicular mucinosis. Mucinossa website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.

Topical corticosteroids mid to high potency —response expected aoopecia 3 months Tretinoin 0. Other conditions that may need to be considered in the differential diagnosis include:. It may persist for months or years and no specific therapy has been found to be effective for patients with idiopathic alopecia mucinosa.

Suggested therapies are based on anecdotal reports or small case series. Indian J Dermatol Venereol Leprol. The cause of alopecia mucinosa is unknown, but it may have something to do with circulating immune complexes and cell-mediated immunity.

Koilonychia Alopecka clubbing behavior: And are there other choices? Lymphocytes were seen infiltrating the follicular epithelium but no atypical lymphocytes were seen. Body odor Chromhidrosis Fox—Fordyce disease. The following options zlopecia been anecdotally reported to be effective; selection is based on individual patient tolerance and comorbidities, and on the comfort level of the prescribing physician. Important to note mucinksa both these cases were not of Alopecia mucinosa, but had a clinical presentation of diffuse acute dermatitis with an incidental finding of follicular mucinosis.

Some papers[ 411 ] have shown good response of follicular mucinosis to minocycline, however, contrary results with very minimal or no improvement has also been reported in patients with Alopecia mucinosa who were treated with minocycline for more than 3 months.

Follicular mucinosis presenting as acute dermatitis with response to dapsone. Usually, primary and acute alopecia mucinosa occurring in children resolves spontaneously. Primary or idiopathic Alopecia mucinosa was first described in by Pinkus. Nil Conflict of Interest: Alopecia mucinosa, also known as follicular mucinosis, describes the appearance of mucin around hair follicles as seen under the microscope.

Alopecia mucinosa is diagnosed by its clinical appearance and supported by histopathological findings on biopsy:. FM has been reported as an incidental finding in a variety of inflammatory skin disorders, such as acne, insect bite reactions, and lichen planus.

He was followed-up at monthly intervals and at the end of 6 months, the lesion had cleared significantly, although not completely and the treatment was stopped. Alopecia mucinosa occurs when mucinous material accumulates in the hair follicles and sebaceous glands.


Alopecia Mucinosa Responding to Antileprosy Treatment: Are we Missing Something?

A year-old boy presented in Septemberwith a hypopigmented and hypoaesthetic shiny patch on the left cheek of few months duration. This page was last edited on 21 Juneat Thus we recommend that in regions endemic for leprosy, such as India, children and young adults who present with single lesions on the face that show follicular mucinosis as the only pathology, be treated with standard MDT.

Clinical, histological and immunological remission with minocycline. In general, patients with idiopathic FM tend to be younger and have fewer and more localized lesions on the head or neck. By registering you consent to the collection and use of your information to provide the products and services you have requested from us and as described in our privacy policy and terms and conditions. Mucin between follicular keratinocytes.

Alopecia Mucinosa Responding to Antileprosy Treatment: Are we Missing Something?

When incidentally encountered microscopically, it may be simply viewed as a histologic reaction pattern. Hydroxychloroquine mg orally, three times daily for 10 days, followed by mg orally, twice daily; response noted within 6 months, begin taper mmucinosa lesions have cleared.

If you have any concerns with your skin or its treatment, see a dermatologist for advice. Three cases with single lesion of Alopecia mucinosa follicular mucinosis were treated with antileprosy treatment and showed rapid and complete resolution of the lesions with no recurrence on extended follow-up. Mucinisa it is too much of coincidence to consider that the response in all patients was alipecia to natural remission, and it is most likely that it was the oral treatment that brought about healing of the lesions.

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