Obedece a la existencia de factores que operan sobre regiones u órganos perturbando alguna de las fuerzas que componen la ley de starling. Transcript of Edema. Edema. Tipos: Circunscrito Generalizado Definición Incremento clínicamente Alteración de las fuerzas de Starling. – Daño capilar. Edema Agudo Pulmonar No Cardiogénico (EAPnC): también denominado de capilar pulmonar, que ocasionará desequilibrio en las fuerzas de Starling, esto.

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Influence of visual experience deprivation on the postnatal development of the microvascular bed in layer IV of the rat visual cortex. The strong relationship that exists between cellular metabolic capacity and regional blood flow leads to the conclusion that a clear understanding of age-related changes in the regulation of blood flow including microvascular architecture, plasticity, and vessel reactivity is essential for understanding the progressive decline in cellular metabolic activity and eventually tissue function with age.

In middle cerebral arteries from Fisher rats, Geary and Buchholz [] starlihg an increase in arterial tone with advancing age, a finding that appears to be, at least in part, secondary to the dysfunction of eNOS-sensitive mechanisms.

These are the only two body parts edems compressed by outside air pressure. Mechanistically, endothelium-dependent relaxing factors EDRFs result in hyperpolarization of smooth muscle cells and dilation, whereas endothelium-derived constriction factors EDCFs result in smooth muscle depolarization and vessel constriction. Thus, at least for the responses to these pharmacological agents, there is no significant decline in plasticity during aging.

A study on the microvasculature of the cerebral cortex. There is evidence that in otherwise healthy humans and animals, age-related changes occur in each of these variables.

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Small changes in arterial tone result in rapid adjustment of regional cerebral blood flow to meet neuronal and metabolic demands. For details, please, refer to the main text. An examination stadling some metabolic and pathophysiological considerations in neural transplantation.


Does cerebral blood flow sharling in healthy aging? Differential metabolic and electrical activity in the somatic sensory cortex of juvenile and adult rats. Age-related decrease of protein kinase G activation in vascular smooth muscle cells.

Third, capillary changes with aging may be multiphasic. Allografts of CNS tissue possess a blood-brain barrier. Accordingly, myogenic responses have been described in several vascular beds e. Ueda H, Moritoki H.

Microcirculación y circulación linfática

The extent of microvascular response appeared to be similar in 1-year-old and 3-year-old rats. In addition, impairments in synaptic efficacy, neurogenesis, glucose metabolism, neurotransmitter levels, and long-term potentiation an electrophysiological correlate of memory are evident. Because venous resistance is relatively low, changes in PV are readily transmitted back to the capillary, and conversely, because arterial resistance is relatively high, changes in PA are poorly transmitted downstream to the capillary.

In addition to activity-induced angiogenesis, adult microvascular plasticity is important clinically. In the latter case, plasma and tissue oncotic pressures may have a negligible influence on the net driving force. Vascular endothelial growth factor VEGF stimulates neurogenesis in vitro and in vivo.

However, equally important is the technical difficulty in associating functional defects that occur in highly specific brain regions with an accurate measurement of flow to these same regions. Unfortunately, the majority of data on microvascular reactivity has been gathered from peripheral vascular beds.

Palade postulated that caveolae shuttled across capillary endothelium carrying cargoes of plasma fluid and proteins and this was subsequently demonstrated experimentally with tracers reviewed in [29].

The extent to which such plasticity is maintained during aging has not been clearly defined but undoubtedly depends on the specific factors eliciting the microvascular response.

Larger lymphatics also have smooth muscle cells.


Alterations in fetal kidney development and elevations in arterial blood pressure in young adult sheep after clinical doses of antenatal glucocorticoids. Morphometric and immunocytochemical studies. The systemic effects edemz the myogenic response are prominent, and they significantly amplify through a positive feedback mechanism the immediate vasoconstrictor effects of pressor agents on systemic pressure.

Outlook for the Future. The putative decrease in afferent vessels raises the question of whether there is a corresponding decrease in cerebral capillaries supplied by the afferent arterioles. Caution is required when comparing data recorded at different sites even if corrected for the volume of soft tissue under study. However, the regulation of CBF is not static, and localized brain regions have the ability to regulate blood flow in response to minute alterations in metabolic requirements of the surrounding tissues.

Age-related changes in rat brain capillaries.

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The mechanosensor may be a heteromultimeric complex. Zagzag D, Capo V.

Biochem Biophys Res Commun. The response in middle-aged rats was less than that in young adults, and fuerzae statistically significant change in microvascular density was elicited in old rats [87].

En la piel de dedos nariz labios y orejas, reg temp. Spontaneous and stretch-activated vasomotion is present which serves to “pump” lymph. The role of polypeptide growth factors in recovery from stroke. There are, in fact, numerous reports of age-related rarefaction or loss of arterioles in many tissues throughout the body including cardiac and skeletal muscle [22—24] ; starlinng, only a few investigators have studied the effects of aging on the density of cerebral arterioles.